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[维生素A缺乏大鼠小肠黏膜水解酶活性的研究]

[Study of hydrolase activity of rat small intestine mucosa with vitamin A deficiency].

作者信息

Leustkiĭ K M, Baran M M, Gorshinskii B M

出版信息

Ukr Biokhim Zh (1978). 1978 Sep-Oct;50(5):604-6.

PMID:726094
Abstract

The activity of amylase, alkaline phosphatase and lipase in the pancreas, in the mucosa and on the surface of small intestine (turned out segments) was studied for elucidating the effect of vitamin A deficiency on the synthesis of the studied enzymes and their translocation to the surface of glycocalix cell membranes. The activity of amylase is established to increase in the homogenate of the pancreas, intestine mucosa and on the surface of cell membranes. The activity of alkaline phosphatase and lipase in the homogenate of small intestine mucosa and in the pancreas lowers. The results obtained evidence for a disturbance in the intestine digestive function with vitamin A deficiency, the may be connected with the damage of the mucosa membrane structures as well as with a disturbance in the biosynthesis of the protein playing a decisive role in formation of secretory products in cells.

摘要

研究了胰腺、小肠黏膜及小肠表面(外翻肠段)中淀粉酶、碱性磷酸酶和脂肪酶的活性,以阐明维生素A缺乏对所研究酶的合成及其向糖萼细胞膜表面转运的影响。结果发现,胰腺、肠黏膜匀浆及细胞膜表面的淀粉酶活性增加。小肠黏膜和胰腺匀浆中的碱性磷酸酶和脂肪酶活性降低。所得结果证明维生素A缺乏会扰乱肠道消化功能,这可能与黏膜膜结构受损以及细胞中分泌产物形成过程中起决定性作用的蛋白质生物合成紊乱有关。

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