Gilmour R F, Ruffy R, Lovelace D E, Mueller T M, Zipes D P
Cardiovasc Res. 1981 Jan;15(1):47-58. doi: 10.1093/cvr/15.1.47.
Acute occlusion of the left anterior descending coronary artery in dogs produced delayed conduction and diminished amplitude of bipolar electrograms recorded from ischaemic zones. Intravenous infusion of ethanol (1.2 g . kg-1), before coronary artery occlusion, delayed conduction and reduced the amplitude of electrograms recorded in normal myocardium, but attenuated ischaemia-induced electrogram changes produced by the subsequent occlusion. Ethanol (0.6 g . kg-1 iv) did not significantly alter activation of electrograms recorded from normal myocardium, but reduced ischaemia-induced electrogram changes and decreased the incidence of ventricular fibrillation elicited by rapid ventricular pacing from five of eight to one of eight dogs. Infusion of 10 or 30% (V/V) ethanol directly into a non-occluded coronary artery significantly increased conduction time and reduced electrogram amplitude recorded in the epicardium perfused by that coronary artery. These effects were more pronounced when ethanol was infused into an occluded coronary artery distal to the site of occlusion. Ethanol did not alter regional myocardial blood flow determined by labelled microspheres during ischaemia. Thus, despite a direct depressant effect on extracellular electrical activity recorded from normal and ischaemic myocardium, ethanol reduced the severity of ischaemia-induced electrogram alterations and decreased the incidence of ventricular fibrillation when given intravenously prior to coronary artery occlusion.
犬左前降支冠状动脉急性闭塞可导致传导延迟，并使缺血区记录的双极电图振幅减小。在冠状动脉闭塞前静脉输注乙醇（1.2 g·kg⁻¹），可使正常心肌记录的电图传导延迟并降低其振幅，但可减轻随后闭塞所产生的缺血性电图改变。乙醇（0.6 g·kg⁻¹静脉注射）对正常心肌记录的电图激活无显著影响，但可减少缺血性电图改变，并使快速心室起搏诱发的心室颤动发生率从8只犬中的5只降至8只犬中的1只。将10%或30%（V/V）乙醇直接注入未闭塞的冠状动脉，可显著延长该冠状动脉灌注的心外膜记录的传导时间并降低电图振幅。当乙醇注入闭塞部位远端的闭塞冠状动脉时，这些效应更为明显。乙醇在缺血期间未改变用标记微球测定的局部心肌血流。因此，尽管乙醇对正常和缺血心肌记录的细胞外电活动有直接抑制作用，但在冠状动脉闭塞前静脉给予乙醇可减轻缺血性电图改变的严重程度并降低心室颤动的发生率。
