Evis M J, Kane K A, Moore M R, Parratt J R
Arch Toxicol. 1986 May;59(1):56-60. doi: 10.1007/BF00263959.
The aim of this study was to investigate whether chronic (3 or 10 months) administration, via the drinking water, of lead (25 ppm) and/or ethanol (25% v/v) altered the susceptibility of the heart to arrhythmias induced either by coronary artery occlusion or noradrenaline infusion in pentobarbitone-anaesthetised male Sprague-Dawley rats. The cardiac effects of acute intravenous infusions of ethanol (17, 33 and 66 mg kg-1 min-1) were also measured. Chronic exposure to ethanol and/or lead in the drinking water had no marked effect on the severity of arrhythmias occurring within the initial 30 min of coronary artery occlusion. In control rats and in those administered ethanol and/or lead for 10 months, noradrenaline (16 micrograms kg-1 min-1 given IV 1 h post-occlusion for a 15-min period) induced a similar number of ectopic beats during the infusion period, although these arrhythmias persisted beyond the infusion period in treated animals only. There was a significant accumulation of lead in the bone but not in the blood of lead-treated rats. Blood ethanol concentrations varied considerably between animals, ranging from 0 to 319 mg %. Ethanol (66 mg kg-1 min-1) given acutely and yielding a blood concentration of 174 mg % had a slight antiarrhythmic effect in this model.
本研究的目的是调查在戊巴比妥麻醉的雄性Sprague-Dawley大鼠中，通过饮用水长期（3或10个月）给予铅（25 ppm）和/或乙醇（25% v/v）是否会改变心脏对冠状动脉闭塞或去甲肾上腺素输注所诱发心律失常的易感性。还测量了急性静脉输注乙醇（17、33和66 mg kg-1 min-1）的心脏效应。长期通过饮用水接触乙醇和/或铅对冠状动脉闭塞最初30分钟内发生的心律失常严重程度没有显著影响。在对照大鼠以及给予乙醇和/或铅10个月的大鼠中，去甲肾上腺素（闭塞后1小时静脉注射16微克 kg-1 min-1，持续15分钟）在输注期间诱发的异位搏动数量相似，尽管这些心律失常仅在接受治疗的动物中在输注期后持续存在。铅处理大鼠的骨骼中铅有显著蓄积，但血液中没有。不同动物之间的血液乙醇浓度差异很大，范围从0到319 mg%。在该模型中，急性给予乙醇（66 mg kg-1 min-1）并使血液浓度达到174 mg%有轻微的抗心律失常作用。
