Scott C S
Clin Exp Immunol. 1981 Apr;44(1):201-10.
The sequential expression of granulocyte membrane receptors for C3b, C3b' and C3d have been investigated in normal human bone marrow and peripheral blood. In particular the relationship between receptor expression and morphological characteristics of granulocyte maturation has been assessed. The result indicate that C3b receptor development precedes that of the Fc-IgG receptor and is present on all neutrophil precursors with the exception of the agranular myeloblast. Furthermore, there is, in contrast to Fc-IgG receptors, no difference (P greater than 0.35) in C3b receptor expression between marrow and peripheral blood segmented neutrophils. An apparent subpopulation of granulocytes also appear to have receptors for C3b' whereas receptors for C3d were not detected at all during granulocyte maturation. The application of these findings to the normal in vivo functions of granulocytes and to the study of abnormal granulocyte populations in myeloproliferative disorders is discussed.
已对正常人骨髓和外周血中粒细胞膜上C3b、C3b'和C3d受体的顺序表达进行了研究。特别评估了受体表达与粒细胞成熟形态特征之间的关系。结果表明，C3b受体的发育先于Fc-IgG受体，除无颗粒的成髓细胞外，所有中性粒细胞前体上均有C3b受体。此外，与Fc-IgG受体不同，骨髓和外周血分叶核中性粒细胞之间C3b受体表达无差异（P大于0.35）。明显有一部分粒细胞似乎也有C3b'受体，而在粒细胞成熟过程中根本未检测到C3d受体。讨论了这些发现应用于粒细胞正常体内功能以及骨髓增殖性疾病中异常粒细胞群体研究的情况。
