Matsuzawa T, Nakata M, Ikeda C, Tachibana A, Yano K
Chemotherapy. 1981;27(5):297-302. doi: 10.1159/000237995.
When guinea pigs received a single intramuscular injection of sisomicin (25 mg/kg) at week 8 of pregnancy, fetal sisomicin concentration at 2 h was highest in the kidneys, followed by the plasma and the cochlea; at 4 h it was not detected in the plasma or the cochlea. When dams were treated with 25 mg/kg during weeks 1-5 of pregnancy, fetal sisomicin concentration in the kidneys was 9 times greater than in the cochlea; in 3-week-old animals, a drug concentration of 4 microgram/g was detected only in the kidneys. When dams were treated during weeks 5-9 of pregnancy, the neonatal drug concentration was highest in the kidneys and the cochlea; no plasma concentration was detected. At 3 weeks of age, the concentration was highest in the kidneys and the cochlea. When lactating dams received sisomicin, only kidneys of suckling animals contained sisomicin at 0.4 microgram/g.
豚鼠在妊娠第8周接受单次肌内注射西索米星（25毫克/千克）后，2小时时胎儿西索米星浓度在肾脏中最高，其次是血浆和耳蜗；4小时时在血浆或耳蜗中未检测到。当母鼠在妊娠第1 - 5周用25毫克/千克治疗时，胎儿肾脏中的西索米星浓度比耳蜗中的高9倍；在3周龄动物中，仅在肾脏中检测到4微克/克的药物浓度。当母鼠在妊娠第5 - 9周接受治疗时，新生动物的药物浓度在肾脏和耳蜗中最高；未检测到血浆浓度。在3周龄时，浓度在肾脏和耳蜗中最高。当哺乳期母鼠接受西索米星时，仅哺乳幼崽的肾脏中含有0.4微克/克的西索米星。
