Matsuzawa T, Nakata M, Tsushima M, Miura H, Akiyoshi M
Toxicology. 1980;17(1):67-71. doi: 10.1016/0300-483x(80)90028-1.
The audiotoxic effect of sisomicin was investigated in guinea pig injected intramuscularly with 6.25, 12.5, 25 and 50 mg/kg of sisomicin sulfate (potential) during weeks 1--5 or 5--9 of pregnancy, and the transplacental effect on their offspring was studied. While, in some dams the higher doses of sisomicin produced a limited effect on the pinna reflex and the outer hair cells of the organ of Corti, no such effects were noted in any of the offspring during the 3-week postnatal observation period.
在妊娠第1至5周或第5至9周期间，给豚鼠肌肉注射6.25、12.5、25和50mg/kg硫酸西索米星（潜在剂量），研究西索米星的耳毒性作用，并研究其对后代的经胎盘影响。虽然在一些母鼠中，较高剂量的西索米星对耳廓反射和柯蒂氏器的外毛细胞产生了有限的影响，但在出生后3周的观察期内，未在任何后代中观察到此类影响。
