Deng L J, Luh K T, Hsieh W C, Ho S W
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1981 Mar;14(1):1-9.
The susceptibilities of 100 clinically significant isolates of Staphylococcus aureus and 45 clinically significant isolates of Staphylococcus epidermidis against various antibiotics were determined by the agar dilution method. Rifampin was the most active of all agents tested against both S. aureus and S. epidermidis. Among the beta-lactam antibiotics, penicillin G was least active, but had the lowest MIC in range. All strains of S. aureus were susceptible to cloxacillin and cephalothin at concentrations of 2 and 4 mcg/ml, respectively. Cloxacillin was less active against S. epidermidis, while cephalothin was more active. Minocycline was more active than doxycycline and tetracycline. Chloramphenicol was not only almost as poor in activity against S. aureus as tetracycline, but also the least active of all agents tested against S. epidermidis. Gentamicin was the most active aminoglycoside. Erythromycin, lincomycin and clindamycin showed the bimodal pattern of susceptibility. These results suggest the marked variability in antibiotic susceptibility of staphylococci.
采用琼脂稀释法测定了100株具有临床意义的金黄色葡萄球菌和45株具有临床意义的表皮葡萄球菌对多种抗生素的敏感性。在所有测试药物中，利福平对金黄色葡萄球菌和表皮葡萄球菌的活性最强。在β-内酰胺类抗生素中，青霉素G活性最低，但最低抑菌浓度范围也最低。所有金黄色葡萄球菌菌株分别在2微克/毫升和4微克/毫升的浓度下对氯唑西林和头孢噻吩敏感。氯唑西林对表皮葡萄球菌的活性较低，而头孢噻吩的活性较高。米诺环素比多西环素和四环素的活性更强。氯霉素不仅对金黄色葡萄球菌的活性几乎与四环素一样差，而且是所有测试药物中对表皮葡萄球菌活性最低的。庆大霉素是活性最强的氨基糖苷类药物。红霉素、林可霉素和克林霉素呈现出双峰敏感性模式。这些结果表明葡萄球菌对抗生素的敏感性存在显著差异。
