Sabath L D, Garner C, Wilcox C, Finland M
Antimicrob Agents Chemother. 1976 Jun;9(6):962-9. doi: 10.1128/AAC.9.6.962.
The susceptibilities of 36 recent isolates of Staphylococcus aureus and 35 recent isolates of Staphylococcus epidermidis were determined against each of 65 antimicrobial agents and against two of them in combination. Rifampin was the most active of all the agents tested against both S. aureus and S. epidermidis. Among the penicillins, cloxacillin, dicloxacillin, and nafcillin were most active, although benzylpenicillin and phenoxymethyl penicillin were more active against susceptible strains. Cephaloridine was the most active of the cephalosporins, and sisomicin was the most active aminoglycoside. Minocycline was more active than the other tetracycline analogues tested. Among the macrolide-lincomycin compounds in clinical use, clindamycin was more active, and lincomycin was less active than erythromycin. The synergy of trimethoprim-sulfamethoxazole was more striking against S. aureus than against S. epidermidis. The median minimal inhibitory concentrations of the penicillins, cephalosporins, and aminoglycosides were lower against S. aureus, whereas the minimal inhibitory concentrations of the tetracyclines were lower against S. epidermidis.
测定了36株近期分离的金黄色葡萄球菌和35株近期分离的表皮葡萄球菌对65种抗菌药物中每种药物以及其中两种药物联合使用时的敏感性。利福平是所有测试药物中对金黄色葡萄球菌和表皮葡萄球菌活性最高的。在青霉素类中，氯唑西林、双氯西林和萘夫西林活性最高，尽管苄青霉素和苯氧甲基青霉素对敏感菌株活性更高。头孢菌素中头孢利定活性最高，西索米星是活性最高的氨基糖苷类。米诺环素比其他测试的四环素类似物活性更高。在临床使用的大环内酯 - 林可霉素类化合物中，克林霉素活性更高，林可霉素活性低于红霉素。甲氧苄啶 - 磺胺甲恶唑的协同作用对金黄色葡萄球菌比对表皮葡萄球菌更显著。青霉素类、头孢菌素类和氨基糖苷类的中位最低抑菌浓度对金黄色葡萄球菌较低，但四环素类的最低抑菌浓度对表皮葡萄球菌较低。
