一种用于同时测量大鼠脑血流量和脑代谢的双示踪剂放射自显影技术。
A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats.
作者信息
Mies G, Niebuhr I, Hossmann K A
出版信息
Eur Neurol. 1981;20(3):188-93. doi: 10.1159/000115232.
Double tracer autoradiographic measurement of cerebral blood flow and glucose consumption was performed in rats using 131I-iodo-antipyrine and 14C-deoxyglucose, respectively. Local coupling of blood flow and metabolism was studied under different types of anesthesia (barbiturate, halothane), following experimental tumor implantation, and during penicillin seizures or spreading depression. Both coupling and uncoupling of flow and metabolism was observed on the same tissue section, indicating a considerable degree of variability in local coupling mechanisms.
分别使用131I-碘安替比林和14C-脱氧葡萄糖对大鼠进行脑血流量和葡萄糖消耗的双示踪剂放射自显影测量。在不同类型的麻醉（巴比妥酸盐、氟烷）下、实验性肿瘤植入后、青霉素癫痫发作或扩散性抑制期间，研究血流量与代谢的局部耦合情况。在同一组织切片上观察到了血流量与代谢的耦合和解耦，这表明局部耦合机制存在相当程度的变异性。
Zotero 插件