Danielsen C C, Gottrup F
Eur Surg Res. 1981;13(3):194-201. doi: 10.1159/000128185.
Collagen synthesis, collagen concentration and collagen content were studied 5, 7, 10, 20 and 40 days postoperatively to elucidate the turnover of collagen in healing incisional wounds in rat stomach and duodenum. Collagen synthesis was elevated relative to total protein synthesis in wound tissues compared to intact tissues and increased throughout the period with peak values at day 5. Also, collagen concentration increased while collagen content remained constant implying equal rates of collagen synthesis and degradation. This shows that the prime tissue response to wounding is changes in collagen metabolism, which correlates with mechanical strength gain.
术后5天、7天、10天、20天和40天对胶原蛋白合成、胶原蛋白浓度和胶原蛋白含量进行了研究，以阐明大鼠胃和十二指肠切口愈合过程中胶原蛋白的更新情况。与完整组织相比，伤口组织中的胶原蛋白合成相对于总蛋白质合成有所升高，且在整个时期内都有所增加，在第5天达到峰值。此外，胶原蛋白浓度增加，而胶原蛋白含量保持不变，这意味着胶原蛋白合成和降解的速率相等。这表明组织对伤口的主要反应是胶原蛋白代谢的变化，这与机械强度的增加相关。
