[Protection of myocardial mitochondria from penetration by calcium ions using isoquinoline and phenothiazine derivatives].

It has been established that malonate-like action of isoquinoline derivatives (papaverine and nospan) on respiratory function of myocardial mitochondria leads to inhibition of the accumulation rate of Ca2+ by these organelles on the use of glutamate and alpha-ketoglutarate as substrates. A greater inhibition of Ca2+ transport rate in the mitochondria is observed in the presence of glutamate. It has been validated theoretically that the decreased intensity of Ca2+ accumulation is aimed at protecting the mitochondria from irreversible lesions in ischemia. Nitroglycerin and sodium nitrite do not affect Ca2+ exchange in the mitochondria.