肝脏疾病中的库普弗细胞增生。活检样本扫描电子显微镜观察证实

Kupffer cell hyperplasia in liver diseases. Demonstration by scanning electron microscopy of biopsy samples.

作者信息

Itoshima T, Kiyotoshi S, Kawaguchi K, Ogawa H, Ohta W, Ito T, Hirakawa H, Shimada Y, Nagashima H

出版信息

Gastroenterol Jpn. 1981;16(3):223-31. doi: 10.1007/BF02815801.

Abstract

Kupffer cells were observed in liver biopsy tissues of 9 cases of liver diseases by scanning electron microscopy to prove Kupffer cell proliferation numerically. Kupffer cell count per 0.01 mm2 of cracked surface of liver lobule was 1.2 +/- 0.3 in the convalescent stage of a mild acute hepatitis case and 1.2 +/- 0.1 in a chronic persistent hepatitis case with slight inflammation. Whereas it was increased to 2.4-5.5 (P less than 0.01) in the convalescent stage of moderate to severe acute hepatitis cases, 1.8 +/- 0.1 (p less than 0.05) in a chronic active hepatitis case, 2.5 +/- 0.3 (p less than 0.001) in an alcoholic portal fibrosis case and 2.2 +/- 0.4 (p less than 0.001) in a liver cirrhosis case. Kupffer cell count per mm3 of liver lobule was estimated roughly 3,500 in the convalescent stage of a mild acute hepatitis case and in a mild chronic persistent hepatitis case and 7,000 to 16,000 in the convalescent stage of moderate to severe acute hepatitis cases.

摘要

通过扫描电子显微镜观察9例肝病患者肝活检组织中的库普弗细胞，以从数量上证明库普弗细胞的增殖情况。在轻度急性肝炎病例的恢复期，每0.01平方毫米肝小叶破裂表面的库普弗细胞计数为1.2±0.3，在轻度炎症的慢性持续性肝炎病例中为1.2±0.1。而在中重度急性肝炎病例的恢复期，该计数增加至2.4 - 5.5（P＜0.01），在慢性活动性肝炎病例中为1.8±0.1（p＜0.05），在酒精性门脉纤维化病例中为2.5±0.3（p＜0.001），在肝硬化病例中为2.2±0.4（p＜0.001）。在轻度急性肝炎病例和轻度慢性持续性肝炎病例的恢复期，每立方毫米肝小叶的库普弗细胞计数估计约为3500，在中重度急性肝炎病例的恢复期为7000至16000。