Quill T E
Int J Psychiatry Med. 1981;11(2):155-60. doi: 10.2190/qa6e-7q65-5kwb-8pr2.
A case of tranylcypromine (Parnate) overdose is presented in which the main toxic effects were headache, obtundation, hypertension, and diffusely peaked T-waves on ECG. The latter effect, which occurred in the absence of hyperkalemia, has not been previously associated with monoamine oxidase inhibitors (MAOI). Recent case reports of tranylcypromine toxicity are briefly reviewed, confirming the potential for hypertension, hypotension, shock, hyperpyrexia, intracranial hemorrhage, agitation, hyperkinesis, coma and death in association with overdosage, or concomitant ingestion of sympathomimetic substances or other drugs. These ECG changes add to the worrisome list of potential toxicities in an era in which MAOI are finding increased clinical use.
本文报告了一例反苯环丙胺（帕那特）过量中毒病例，主要中毒症状为头痛、意识模糊、高血压以及心电图上T波广泛高尖。后一种效应在无高钾血症的情况下出现，此前尚未发现与单胺氧化酶抑制剂（MAOI）有关。本文简要回顾了近期反苯环丙胺中毒的病例报告，证实了过量服用或同时摄入拟交感神经物质或其他药物时，可能出现高血压、低血压、休克、高热、颅内出血、激越、运动亢进、昏迷及死亡。在MAOI临床应用日益增加的时代，这些心电图改变使潜在毒性的令人担忧的清单又增加了一项。
