反苯环丙胺（“帕纳特”）过量：血浆中反苯环丙胺浓度及单胺氧化酶抑制活性的测定以及苯丙胺类药物的鉴定

Tranylcypromine ('Parnate') overdose: measurement of tranylcypromine concentrations and MAO inhibitory activity and identification of amphetamines in plasma.

作者信息

Youdim M B, Aronson J K, Blau K, Green A R, Grahame-Smith D G

出版信息

Psychol Med. 1979 May;9(2):377-82. doi: 10.1017/s0033291700030890.

PMID:472083

Abstract

A case of tranylcypromine overdose is reported. Tranylcypromine, amphetamine methamphetamine and phenylethylamine were detected in the plasma by gas chromatography and their identity confirmed by mass spectrometry. The data suggested that the amphetamines were metabolic products of tranylcypromine. Platelet monoamine oxidase activity was more than 95% inhibited during the 72 h after the overdose despite complete clinical recovery by that time. The possible role of amphetamines and phenylethylamine in causing the clinical manifestations of tranylcypromine overdose is discussed.

摘要

报告了一例反苯环丙胺过量中毒病例。通过气相色谱法在血浆中检测到反苯环丙胺、苯丙胺、甲基苯丙胺和苯乙胺，并通过质谱法确认了它们的身份。数据表明，苯丙胺类物质是反苯环丙胺的代谢产物。尽管在过量中毒后72小时内临床已完全康复，但血小板单胺氧化酶活性在这段时间内被抑制了95%以上。文中讨论了苯丙胺类物质和苯乙胺在反苯环丙胺过量中毒临床表现中可能起到的作用。