Brook J G, Aviram M, Luboshitzky R, Barzilai D
Isr J Med Sci. 1981 May;17(5):318-22.
Concentrations of high density lipoprotein (HDL) and its subfractions were contrasted in two groups of patients with hypercholesterolemia and a control group of normocholesterolemic subjects. HDL-cholesterol and HDL-protein were low in patients with Type IIa hyperlipoproteinemia, but elevated in patients with primary hypothyroidism. HDL-3 levels were low whereas those of HDL-2 remained unchanged in patients with Type IIa hyperlipoproteinemia. In contrast, in the hypothyroid patients, HDL-3 remained unchanged, while HDL-2 levels were high. The role of HDL in the development of arteriosclerosis in patients with primary hypothyroidism is therefore questioned. Our findings also suggest that measurement of HDL-cholesterol alone cannot be regarded as an accurate indicator of changes in total HDL concentration in different clinical situations.
对两组高胆固醇血症患者和一组正常胆固醇水平的对照受试者的高密度脂蛋白（HDL）及其亚组分浓度进行了对比。IIa型高脂蛋白血症患者的HDL胆固醇和HDL蛋白水平较低，但原发性甲状腺功能减退患者的这些指标升高。IIa型高脂蛋白血症患者的HDL-3水平较低，而HDL-2水平保持不变。相比之下，甲状腺功能减退患者的HDL-3保持不变，而HDL-2水平较高。因此，HDL在原发性甲状腺功能减退患者动脉粥样硬化发展中的作用受到质疑。我们的研究结果还表明，仅测量HDL胆固醇不能被视为不同临床情况下总HDL浓度变化的准确指标。
