未经训练的大鼠对跑步机运动的心血管反应。

Cardiovascular response to treadmill exercise in untrained rats.

作者信息

Gleeson T T, Baldwin K M

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun;50(6):1206-11. doi: 10.1152/jappl.1981.50.6.1206.

DOI:10.1152/jappl.1981.50.6.1206

Abstract

Oxygen consumption (Vo2), cardiac output (Q), heart rate (HR), stroke volume (SV), and oxygen extraction from blood (Cao2-Cvo2) were measured in untrained rats, both at rest and during treadmill running at various speeds (10-41 m/min). Vo2 increased linearly as a function of running speed, and maximal values (83 ml O2.kg-1 min-1) represented a five-fold increase over resting values. Q, HR, SV, and Cao2-Cvo2 increased linearly as functions of Vo2. Mixed venous oxygen content (Cao2) decreased with increasing Vo2; whereas arterial oxygen content (Cao2) remained independent of Vo2; whereas arterial oxygen content (Cao2) remained independent of Vo2, averaging 19 vol%. Maximal values of these variables and their relationship to Vo2 were as follows: Q = 4.3 Vo2 + 184; Qmax = 543 ml.kg-1.min-1, HR = 3.02 Vo2 + 340; HRmax 595 beats.min-1; SV = 0.004 Vo2 + 0.603; SVmax = 0.92 ml.kg-1.beat-1; Cao2-Cvo2 = 0.13 Vo2 + 5.62; Cao2-Cvo2max = 15.5 vol%.; Cvo2 = -0.12 Vo2 + 12.94; Cvo2min - 3.4 vol%. These data suggest that HR, SV, and Cao2-Cvo2 make significant contributions to the augmentation of Vo2 in the exercising rat.

摘要

在未受过训练的大鼠中，测量了静息状态以及在跑步机上以不同速度（10 - 41米/分钟）跑步期间的耗氧量（Vo2）、心输出量（Q）、心率（HR）、每搏输出量（SV）和血液氧摄取量（Cao2 - Cvo2）。Vo2随跑步速度呈线性增加，最大值（83毫升O2·千克-1·分钟-1）比静息值增加了五倍。Q、HR、SV和Cao2 - Cvo2随Vo2呈线性增加。混合静脉血氧含量（Cao2）随Vo2增加而降低；而动脉血氧含量（Cao2）与Vo2无关，平均为19体积%。这些变量的最大值及其与Vo2的关系如下：Q = 4.3Vo2 + 184；Qmax = 543毫升·千克-1·分钟-1，HR = 3.02Vo2 + 340；HRmax = 595次/分钟；SV = 0.004Vo2 + 0.603；SVmax = 0.92毫升·千克-1·次-1；Cao2 - Cvo2 = 0.13Vo2 + 5.62；Cao2 - Cvo2max = 15.5体积%；Cvo2 = -0.12Vo2 + 12.94；Cvo2min = 3.4体积%。这些数据表明，HR、SV和Cao2 - Cvo2对运动大鼠Vo2的增加有显著贡献。