Johnstone I B, Blackwell T E
Can Vet J. 1984 May;25(5):195-8.
Hemostatic studies were conducted on a five year old Belgian mare presented two days postpartum with colic and laminitis that was unresponsive to treatment.The mare was moderately thrombocytopenic with plasma fibrinogen levels more than twice that of a normal control horse. Platelet function as evaluated by aggregometry indicated that the circulating platelets were markedly hyporesponsive. Activated partial thromboplastin times and prothrombin times were prolonged. Para-coagulation tests (protamine sulfate and ethanol gelation) were strongly positive and fibrin degradation products were significantly elevated in the serum.The laboratory data suggested that the clinical bleeding was the result of the development of disseminated intravascular coagulation. The data were compatible with intravascular activation of the clotting mechanism, consumption of hemostatic factors, inhibition of platelet function and enhanced stimulation of the fibrinolytic mechanism.This report illustrates the complexity of the hemostatic abnormalities associated with pathological overactivation of the hemostatic mechanism. Factors such as tissue thromboplastins and/or endotoxins can stimulate disseminated intravascular coagulation, particularly during pregnancy or in the early postpartum period when a physiological "hypercoagulable" state already exists.
对一匹5岁的比利时母马进行了止血研究。这匹母马产后两天出现腹痛和蹄叶炎，治疗无效。该母马血小板中度减少，血浆纤维蛋白原水平是正常对照马的两倍多。通过血小板聚集试验评估的血小板功能表明，循环中的血小板反应明显低下。活化部分凝血活酶时间和凝血酶原时间延长。副凝血试验（硫酸鱼精蛋白和乙醇凝胶试验）呈强阳性，血清中纤维蛋白降解产物显著升高。实验室数据表明，临床出血是弥散性血管内凝血发展的结果。这些数据与凝血机制的血管内激活、止血因子的消耗、血小板功能的抑制以及纤维蛋白溶解机制的增强刺激相符。本报告说明了与止血机制病理性过度激活相关的止血异常的复杂性。组织凝血活酶和/或内毒素等因素可刺激弥散性血管内凝血，特别是在妊娠期间或产后早期，此时生理上的“高凝”状态已经存在。
