在动物模型中研究5-氟尿嘧啶（5-FU）和卡莫司汀（BCNU）辅助化疗对结肠腺癌的疗效。
Studies in an animal model on the effectiveness of adjuvant chemotherapy with 5-FU and BCNU in cases of colorectal adenocarcinoma.
作者信息
Schmitz R, Hüper J, Pichlmayr R
出版信息
J Cancer Res Clin Oncol. 1981;100(2):213-20. doi: 10.1007/BF00403367.
Abstract
The effect of combined chemotherapy with 5-FU and BCNU on ten well differentiated human adenocarcinomas of different stages following xenotransplantation and growth in syngeneic balb/c nude mice collectives was investigated. With a tumor take of approximately 90%, it was found that marked remissions up to 43% of the original volume were only obtained with those transplant tumors initially classified as Dukes A and B; carcinomas graded Dukes C/D underwent no significant remission. Pathohistological findings during tumor remission revealed large amounts of fibrotic tissue together with surviving nests of tumor cells.
摘要
研究了5-氟尿嘧啶（5-FU）和卡氮芥（BCNU）联合化疗对10例不同分期的高分化人腺癌在同基因balb/c裸鼠群体中异种移植并生长后的影响。肿瘤接种成功率约为90%，结果发现，只有最初分类为Dukes A和B期的移植肿瘤获得了显著缓解，缓解率高达原始体积的43%；Dukes C/D级的癌没有明显缓解。肿瘤缓解期间的病理组织学检查发现大量纤维化组织以及存活的肿瘤细胞巢。
相似文献
1
Studies in an animal model on the effectiveness of adjuvant chemotherapy with 5-FU and BCNU in cases of colorectal adenocarcinoma.在动物模型中研究5-氟尿嘧啶（5-FU）和卡莫司汀（BCNU）辅助化疗对结肠腺癌的疗效。
J Cancer Res Clin Oncol. 1981;100(2):213-20. doi: 10.1007/BF00403367.
2
[Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 1. Experiments to test the feasibility of combined chemotherapy with VCR and 5-FU (author's transl)].先天性胸腺发育不全（“裸鼠”）生长的人结肠腺癌的辅助化疗。1. 用长春新碱和5-氟尿嘧啶联合化疗可行性的实验（作者译）
J Cancer Res Clin Oncol. 1980;96(3):269-79. doi: 10.1007/BF00408099.
3
The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation.卡莫司汀植入剂与替莫唑胺治疗新诊断的高级别胶质瘤的有效性和成本效益：一项系统评价与经济学评估
Health Technol Assess. 2007 Nov;11(45):iii-iv, ix-221. doi: 10.3310/hta11450.
4
Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 2. Tumor remission following treatment with 5-FU and VCR of xenotransplanted primary human colorectal adenocarcinomas.先天性胸腺发育不良（“裸鼠”）饲养的小鼠体内生长的人结肠腺癌的辅助化疗。2. 人原发性结肠腺癌异种移植瘤经5-氟尿嘧啶和长春新碱治疗后的肿瘤缓解情况。
J Cancer Res Clin Oncol. 1980;97(1):15-21. doi: 10.1007/BF00411274.
5
Postoperative adjuvant chemotherapy in rectal cancer operated for cure.针对接受根治性手术的直肠癌患者的术后辅助化疗。
Cochrane Database Syst Rev. 2012 Mar 14;2012(3):CD004078. doi: 10.1002/14651858.CD004078.pub2.
6
The clinical and cost-effectiveness of oxaliplatin and capecitabine for the adjuvant treatment of colon cancer: systematic review and economic evaluation.奥沙利铂和卡培他滨辅助治疗结肠癌的临床疗效与成本效益：系统评价与经济学评估
Health Technol Assess. 2006 Nov;10(41):iii-iv, xi-xiv, 1-185. doi: 10.3310/hta10410.
7
The assessment of response of murine transplantable colon tumors to combination chemotherapy.小鼠可移植性结肠肿瘤对联合化疗反应的评估。
J Cancer Res Clin Oncol. 1982;103(2):119-26. doi: 10.1007/BF00409642.
8
A systematic overview of chemotherapy effects in colorectal cancer.结直肠癌化疗效果的系统综述。
Acta Oncol. 2001;40(2-3):282-308. doi: 10.1080/02841860151116367.
9
Chemotherapy of human colorectal tumor xenografts in athymic mice with clinically active drugs: 5-fluorouracil and 1-3-bis-(-2-chloroethyl)-1-nitrosourea (BCNU). Comparison with doxorubicin derivatives: 4'deoxydoxorubicin and 4'-O-methyldoxorubicin.
Int J Cancer. 1981 Jan 15;27(1):5-13. doi: 10.1002/ijc.2910270103.
10
Preclinical evaluation of 9-chloro-2-methylellipticinium acetate alone and in combination with conventional anticancer drugs for the treatment of human brain tumor xenografts.单独及与传统抗癌药物联合使用的9-氯-2-甲基玫瑰树碱醋酸盐对人脑肿瘤异种移植瘤治疗的临床前评估。
J Cancer Res Clin Oncol. 1998 Jan;124(1):19-26. doi: 10.1007/s004320050128.
引用本文的文献
1
Combination chemotherapy with 5-fluorouracil (5FU) and 1,3-bis(2-chloro-ethyl)-1-nitrosourea (BCNU) prolongs survival of rats with dimethylhydrazine-induced colon cancer.5-氟尿嘧啶（5FU）与1,3-双（2-氯乙基）-1-亚硝基脲（BCNU）联合化疗可延长二甲基肼诱导的结肠癌大鼠的生存期。
Gut. 1983 Nov;24(11):1041-7. doi: 10.1136/gut.24.11.1041.
2
Effects of steroid hormone therapy on primarily xenotransplanted human colorectal adenocarcinomas.类固醇激素疗法对主要为异种移植的人结肠腺癌的影响。
J Cancer Res Clin Oncol. 1984;108(3):345-50. doi: 10.1007/BF00390470.
3
Effect of steroid hormones on human colorectal adenocarcinoma xenografts, of known steroid-receptor status, in nude mice.类固醇激素对已知类固醇受体状态的人结肠腺癌裸鼠异种移植瘤的影响。
J Cancer Res Clin Oncol. 1989;115(5):439-44. doi: 10.1007/BF00393333.
本文引用的文献
1
Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 2. Tumor remission following treatment with 5-FU and VCR of xenotransplanted primary human colorectal adenocarcinomas.先天性胸腺发育不良（“裸鼠”）饲养的小鼠体内生长的人结肠腺癌的辅助化疗。2. 人原发性结肠腺癌异种移植瘤经5-氟尿嘧啶和长春新碱治疗后的肿瘤缓解情况。
J Cancer Res Clin Oncol. 1980;97(1):15-21. doi: 10.1007/BF00411274.
2
Combination chemotherapy in gastrointestinal cancer.胃肠道癌的联合化疗
Cancer Res. 1970 May;30(5):1425-8.
3
[Indications and results of cytostatic therapy in gastrointestinal tumors].
Schweiz Med Wochenschr. 1973 Feb 3;103(5):171-8.
4
Therapy for gastrointestinal cancer with the nitrosoureas alone and in drug combination.单独使用亚硝基脲类药物以及联合用药治疗胃肠道癌。
Cancer Treat Rep. 1976 Jun;60(6):729-32.
5
[Colonic cancer--diagnosis, check-up, prevention].[结肠癌——诊断、检查、预防]
Internist (Berl). 1979 Jan;20(1):39-43.
6
Clinical management of advanced gastrointestinal cancer.
Cancer. 1975 Aug;36(2):675-82. doi: 10.1002/1097-0142(197508)36:2+<675::aid-cncr2820360810>3.0.co;2-a.
Zotero 插件