Cowen D M, Siegerstetter J, Janik A C, Double J A
J Cancer Res Clin Oncol. 1982;103(2):119-26. doi: 10.1007/BF00409642.
The mouse adenocarcinoma of the colon (MAC) system, which has been shown to be a good model for human colorectal carcinoma in terms of its chemosensitivity, was tested with two modified human protocols (MeCCNU + 5 FU, BCNU + 5 FU) in an attempt to evaluate its suitability as a model for developing new regimens of combination chemotherapy for treating patients with colorectal carcinoma. This attempted evaluation raised problems regarding, firstly, the length of time available before tumours became too large in control and non-responding hosts to maintain adequate mobility and, secondly the assessment of response to the drugs. The commencement of drug administration 3 days after transplantation and the assessment of response by measuring delay in time for tumor growth to reach a given volume, with the results analysed by Gehan's (generalised Wilcoxon) test, gave a workable method of evaluation. This method is presented as being suitable for use in the study of transplantable solid tumor lines as models for combination chemotherapy.
小鼠结肠腺癌（MAC）系统在化学敏感性方面已被证明是人类结直肠癌的良好模型，用两种改良的人类方案（甲环亚硝脲+5-氟尿嘧啶、卡氮芥+5-氟尿嘧啶）对其进行了测试，试图评估其作为开发治疗结直肠癌患者联合化疗新方案模型的适用性。这种尝试性评估引发了一些问题，首先，在对照宿主和无反应宿主中，肿瘤变得过大以至于无法保持足够活动能力之前可用的时间长度；其次是对药物反应的评估。移植后3天开始给药，并通过测量肿瘤生长达到给定体积的时间延迟来评估反应，结果用Gehan（广义威尔科克森）检验进行分析，给出了一种可行的评估方法。该方法适用于作为联合化疗模型的可移植实体瘤系的研究。
