Sato I, Hasegawa Y, Takahashi N, Hirata Y, Shimomura K, Hotta K
J Gerontol. 1981 Sep;36(5):564-72. doi: 10.1093/geronj/36.5.564.
Heart rate control function at rest and during exercise in regard to age were studied in 39 healthy male volunteers (age 15 to 75). The heart rate control function during exercise was evaluated by using system analysis of heart rate response to two-step exercises (66 and 84 steps/min). No age-related changes were found in the resting heart rate at supine position or in oxygen consumption at upright rest and during the exercises. However, the mean value and the magnitude of variation of the heart rate at upright rest and the difference of heart rate at upright and supine rest showed significant negative correlations with age. As age advanced, the transfer function of the system during exercise exhibited characteristic changes depending on the frequency ranges. These findings suggest that activity of both sympathetic and parasympathetic nervous systems were depressed at rest, and that contributions of sympathetic and vagal nervous systems during exercise are more enhanced and more depressed, respectively, in older subjects than in younger subjects.
对39名健康男性志愿者（年龄15至75岁）在静息和运动状态下与年龄相关的心率控制功能进行了研究。通过对心率对两步运动（66步/分钟和84步/分钟）的反应进行系统分析，评估运动期间的心率控制功能。仰卧位静息心率、直立休息时和运动期间的耗氧量均未发现与年龄相关的变化。然而，直立休息时心率的平均值和变化幅度以及直立和仰卧休息时心率的差异与年龄呈显著负相关。随着年龄的增长，运动期间系统的传递函数根据频率范围呈现出特征性变化。这些发现表明，交感神经系统和副交感神经系统的活动在静息时均受到抑制，并且在运动期间，老年受试者交感神经系统和迷走神经系统的作用分别比年轻受试者增强和抑制得更多。
