Bate C M, Grunewald E B
J Embryol Exp Morphol. 1981 Feb;61:317-30.
The intersegmental connectives in the locust central nervous system are initiated by the axons of early differentiating neuron trios. Using a combination of electron microscopy and fluorescent dye injection we have shown that the axons of these cells grow out anteriorly and posteriorly in each segment along a basement membrane, and link together at the segment borders to form continuous longitudinal pathways on each side of the developing nervous system. These early neurons are the progeny of a second class of precursor cell, the midline precursors, which are distinct from the segmental neuroblasts. Like the neuroblasts, the midline precursors are arranged in a standard segmentally repeated pattern. This and the standard pattern of axon outgrowth in different segments suggest that the nervous system develops to a common, segmentally repeated programme.
蝗虫中枢神经系统中的节间连接由早期分化的神经元三联体的轴突起始。通过结合电子显微镜和荧光染料注射技术，我们发现这些细胞的轴突在每个节段沿着基底膜向前和向后生长，并在节段边界处连接在一起，在发育中的神经系统两侧形成连续的纵向通路。这些早期神经元是第二类前体细胞即中线前体细胞的后代，中线前体细胞与节段神经母细胞不同。与神经母细胞一样，中线前体细胞也以标准的节段重复模式排列。这以及不同节段中轴突生长的标准模式表明，神经系统按照一个共同的、节段重复的程序发育。
