淋巴细胞因子介导的骨吸收需要内源性前列腺素的合成。
Lymphokine-mediated bone resorption requires endogenous prostaglandin synthesis.
作者信息
Bockman R S, Repo M A
出版信息
J Exp Med. 1981 Aug 1;154(2):529-34. doi: 10.1084/jem.154.2.529.
Abstract
Enhanced synthesis of prostaglandin (PG) E by explanted fetal rat bones was initiated by lymphocyte-conditioned media but not by physiological levels of parathyroid hormone. Rapid release of PGE from bone occurred only when the lymphokine was present. Synthesis of PGE preceded and was necessary for the bone resorption caused by the lymphokine preparation. Local production of prostaglandins in response to inflammatory cell or tumor-derived factors may in part be responsible for the localized bone loss that occurs in certain pathological states.
摘要
淋巴细胞条件培养基可引发体外培养的胎鼠骨骼中前列腺素（PG）E的合成增强，而生理水平的甲状旁腺激素则无此作用。只有当淋巴因子存在时，PGE才会从骨骼中快速释放。PGE的合成先于淋巴因子制剂引起的骨吸收，并且是其必要条件。炎症细胞或肿瘤衍生因子引发的前列腺素局部产生可能部分导致了某些病理状态下发生的局部骨质流失。
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