Klein D N, Williamson P
J Nerv Ment Dis. 1981 Aug;169(8):497-502. doi: 10.1097/00005053-198108000-00005.
Because affective symptomatology and premorbid adjustment are both strongly associated with outcome in schizophrenia, recent investigators have suggested that these two variables may be related to one another. In order to test this hypothesis, 45 schizophrenics were interviewed and rated on standardized and reliable measures of affective symptomatology and premorbid adjustment. The results indicated that schizophrenics with concurrent affective syndromes did not differ from nonaffective schizophrenics on several indices of premorbid adjustment. In addition, only one of 22 affective signs and symptoms, depression, was significantly related to premorbid adjustment. These findings suggest that the good-poor premorbid dimension and the schizoaffective-schizophrenic distinction are largely independent, and that future prognostic studies should include measures of both variables in order to determine their relative and pooled predictive power.
由于情感症状学和病前适应都与精神分裂症的预后密切相关，最近的研究者认为这两个变量可能相互关联。为了验证这一假设，对45名精神分裂症患者进行了访谈，并根据情感症状学和病前适应的标准化可靠测量方法进行评分。结果表明，伴有情感综合征的精神分裂症患者在病前适应的几个指标上与非情感性精神分裂症患者没有差异。此外，22种情感症状和体征中只有一种，即抑郁，与病前适应显著相关。这些发现表明，病前适应的好坏维度与精神分裂症-情感性精神障碍的区分在很大程度上是独立的，未来的预后研究应包括这两个变量的测量，以确定它们的相对和综合预测能力。
