Das M, Dixit R, Seth P K, Mukhtar H
J Neurochem. 1981 Apr;36(4):1439-42. doi: 10.1111/j.1471-4159.1981.tb00584.x.
Glutathione-S-transferase activity in the brain of male mammals (rat and mouse) was found to be relatively lower than in that of females. In contrast, the male aves (pigeon, kite, vulture, and crow) exhibited comparatively higher activity in brain glutathione-S-transferase than the corresponding females. Postnatal development of cytosolic glutathione-S-transferase activity in the rat brain was also investigated. The day-7 rats showed a low activity of 48 nmol/min/mg protein that gradually increased 3.2-fold over the age of 28 days. No striking differences in brain enzyme activities were observed between the 35- and 90-day-old rats. Discrete brain regions of immature rats were found to possess considerable but lower quantities of glutathione-S-transferase activity than those of the adults. The activity increased with the onset of development and attained a steady state after 21 days of age.
研究发现，雄性哺乳动物（大鼠和小鼠）大脑中的谷胱甘肽 - S - 转移酶活性相对低于雌性。相比之下，雄性鸟类（鸽子、鸢、秃鹫和乌鸦）大脑中的谷胱甘肽 - S - 转移酶活性相对高于相应的雌性。还对大鼠大脑中胞质谷胱甘肽 - S - 转移酶活性的出生后发育进行了研究。7日龄大鼠的活性较低，为48 nmol/分钟/毫克蛋白质，在28日龄时逐渐增加了3.2倍。在35日龄和90日龄的大鼠之间未观察到大脑酶活性有显著差异。未成熟大鼠的离散脑区被发现具有相当数量但比成年大鼠低的谷胱甘肽 - S - 转移酶活性。该活性随着发育开始而增加，并在21日龄后达到稳定状态。
