Hendry S H, Jones E G
J Neurosci. 1981 Apr;1(4):390-408. doi: 10.1523/JNEUROSCI.01-04-00390.1981.
Neurons accumulating [3H]gamma-aminobutyric acid (GABA) were identified autoradiographically in frozen and plastic sections after injection of the material in the monkey somatic sensory (areas 3, 1, and 2), motor (area 4), and parietal (area 5) cortex following intravenous administration of a GABA transaminase inhibitor, amino-oxyacetic acid. Two general forms of labeled cells are recognized: those with large diameter (15- to 20-micrometer) somata, probably corresponding to the basket cells of Golgi studies, and those with small diameter (6- to 12-micrometer) somata, probably corresponding to several other types. The sizes and laminar distributions of labeled cells in the cytoarchitectonic fields of the first somatic sensory are (SI) are similar. In these areas, the greatest concentrations of labeled cells are in layer II, in layer IV, and in the superficial stratum of layer IV. In area 5, there are many fewer labeled cells in layer IV. In area 4, the labeled cells are larger and distributed more homogeneously, though there are fewer in layer VI. The large labeled cell type is concentrated in layers III and V of all areas. The smaller labeled types are found in all other layers, including layer I. In layer IV, they form approximately 40% of the total small-celled neuronal population.
在静脉注射γ-氨基丁酸转氨酶抑制剂氨基氧乙酸后，将[³H]γ-氨基丁酸（GABA）注入猴子的躯体感觉皮层（3、1和2区）、运动皮层（4区）和顶叶皮层（5区），然后通过放射自显影法在冰冻切片和塑料切片中鉴定积累GABA的神经元。可识别出两种一般类型的标记细胞：一种是具有大直径（15至20微米）胞体的细胞，可能对应于高尔基研究中的篮状细胞；另一种是具有小直径（6至12微米）胞体的细胞，可能对应于其他几种类型。在第一躯体感觉区（SI）的细胞构筑区域中，标记细胞的大小和层状分布相似。在这些区域，标记细胞的最大浓度位于第II层、第IV层和第IV层的浅层。在5区，第IV层中的标记细胞要少得多。在4区，标记细胞更大且分布更均匀，尽管第VI层中的细胞较少。大的标记细胞类型集中在所有区域的第III层和第V层。较小的标记类型存在于所有其他层，包括第I层。在第IV层，它们约占小细胞神经元总数的40%。
