某些香烟烟雾成分及其他化合物对兔肺9000g上清液中苯并(a)芘代谢的影响。

The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant.

Hulshoff A, Lubawy W C, Kostenbauder H B

Xenobiotica. 1978 Nov;8(11):711-7. doi: 10.3109/00498257809069583.

Abstract

The inhibitory effects, of a number of compounds, on the formation of two groups of benzo(a)pyrene metabolites in rabbit lung homogenates (9000 g supernatant) have been investigated. 2. The inhibitors comprised two groups: those inhibiting primarily benzo(a)pyrene hydroxylase activity, and those inhibiting the activity of the epoxide-metabolizing enzymes as well as hydroxylase activity. Phenol, 1-naphthol, nicotine and acetone belong to the former group; naphthalene, anthracene and chlorpromazine to the latter group. 3. The most active inhibitors also caused a significant decrease in the amount of benzo(a)pyrene bound covalently to tissue macromolecules.

摘要

已研究了多种化合物对兔肺匀浆（9000g 上清液）中两组苯并(a)芘代谢产物形成的抑制作用。2. 抑制剂分为两组：主要抑制苯并(a)芘羟化酶活性的化合物，以及同时抑制环氧化物代谢酶活性和羟化酶活性的化合物。苯酚、1-萘酚、尼古丁和丙酮属于前一组；萘、蒽和氯丙嗪属于后一组。3. 活性最强的抑制剂还使与组织大分子共价结合的苯并(a)芘量显著减少。