Hudák A, Tátrai E, Lörincz M, Barcza G, Ungváry G
Morphol Igazsagugyi Orv Sz. 1980 Oct;20(4):261-8.
CFY rats from the 7th to the 14th days of pregnancy were given benzole to inhale during 24 hours a day in doses 150, 450, 1500 or 3000 mg/m3 (50, 150, 500 or 1000 ppm). It was established that benzole has no teratogenous effect in rats. Frequency of the obvious malformations of the scelet and soft tissues has not increase at any doses given. The concentration of benzole 150 mg/m3 has induced moderate, 450 mg/m3 marked maternal and foetal toxicity i.e. increase of the maternal mortality rate, damage to the circulation, decrease in the gain of the body weight and that of the placenta, increase of the foetal mortality rate (early and late) and retardation of the foetal development. Further increase of the concentration of the benzole was not followed by more severe toxical symptoms. Authors conclude, that women already before the onset of the planned pregnancy should avoid benzole exposition.
在妊娠第7至14天的CFY大鼠，每天24小时吸入剂量为150、450、1500或3000毫克/立方米（50、150、500或1000 ppm）的苯。已确定苯对大鼠无致畸作用。在给予任何剂量的情况下，骨骼和软组织明显畸形的发生率均未增加。150毫克/立方米的苯浓度已引起中度毒性，450毫克/立方米的苯浓度已引起明显的母体和胎儿毒性，即母体死亡率增加、循环系统受损、体重和胎盘增重减少、胎儿死亡率（早期和晚期）增加以及胎儿发育迟缓。苯浓度的进一步增加并未伴随更严重的毒性症状。作者得出结论，计划怀孕的女性在怀孕前就应避免接触苯。
