Tátrai E, Ungváry G, Hudák A, Rodics K, Lörincz M, Barcza G
J Hyg Epidemiol Microbiol Immunol. 1980;24(3):363-71.
CFY rats were exposed to continuous benzene inhalation 24 h/day from day 7 to day 14 of gestation at 150, 450, 1500, or 3000 mg/m3 (50, 150, 500, or 1000 ppm) atmospheric concentrations. None of the benzene concentrations used proved to be teratogenic. There was no increase in the incidence of external, visceral, or skeletal malformations. Benzene inhalation at a 150 mg/m3 concentration brought about a slight toxic effect at a 450 mg/m3 concentration a more pronounced effect on both mothers and fetuses. The toxic effects were manifest as an increase in maternal mortality, circulatory damage, decreased gain in body weight, decrease in the weight of the placenta in the mothers and an increase in mortality (early and late), retardation of development (weight and skeleton) in the fetuses. No further change in the parameters was seen with further increases in benzene concentration. Avoidance of the risks of benzene exposure seems desirable before the commencement of planned pregnancy in the human.
在妊娠第7天至第14天，将CFY大鼠每天24小时暴露于浓度分别为150、450、1500或3000毫克/立方米（50、150、500或1000 ppm）的持续吸入苯环境中。所使用的任何苯浓度均未被证明具有致畸性。外部、内脏或骨骼畸形的发生率没有增加。吸入150毫克/立方米浓度的苯会产生轻微毒性作用，吸入450毫克/立方米浓度的苯对母体和胎儿的影响更为明显。毒性作用表现为母体死亡率增加、循环系统损伤、体重增加减少、母体胎盘重量减轻以及死亡率（早期和晚期）增加、胎儿发育（体重和骨骼）迟缓。随着苯浓度进一步升高，这些参数未见进一步变化。在人类计划怀孕之前，避免苯暴露风险似乎是可取的。
