Brazy J E, Little V, Grimm J, Pupkin M
Obstet Gynecol. 1981 Sep;58(3):297-303.
Seventy patients treated with isoxsuprine for premature labor were studied. In patients with intact membranes prolongation of pregnancy for more than 7 days occurred in 77% of women with 50% cervical effacement or less and 3 cm dilatation or less at the initiation of therapy, and in none with more than 50% effacement and more than 3 cm dilatation. Cervical effacement was the primary factor in determining success. Cord isoxsuprine concentrations averaged 90% of maternal concentrations at delivery. Maternal and cord isoxsuprine concentrations at delivery were inversely correlated with the drug-free interval before delivery. An interval of more than 5 hours was necessary to attain a cord concentration of less than 2 ng/ml, a level not associated with neonatal problems. Drug-free intervals of 2 hours or less usually resulted in cord isoxsuprine values of more than 10 ng/ml, levels that are associated with severe neonatal problems. Seventy-seven percent of infants with cord isoxsuprine concentrations of more than 2 ng/ml and 91% with values of more than 10 ng/ml were delivered of mothers with more than 3 cm dilatation or more than 50% effacement at the initiation or reinstitution of intravenous therapy. Most severe neonatal problems are preventable if patients are selected carefully.
对70例接受异克舒令治疗早产的患者进行了研究。对于胎膜完整的患者，在治疗开始时宫颈消退50%或更少且扩张3cm或更小的女性中，77%的患者妊娠延长超过7天，而宫颈消退超过50%且扩张超过3cm的患者无一妊娠延长。宫颈消退是决定治疗成功与否的主要因素。分娩时脐带异克舒令浓度平均为母体浓度的90%。分娩时母体和脐带异克舒令浓度与分娩前无药间隔呈负相关。要使脐带浓度低于2ng/ml（一个与新生儿问题无关的水平），无药间隔需超过5小时。2小时或更短的无药间隔通常导致脐带异克舒令值超过10ng/ml，这一水平与严重的新生儿问题相关。静脉治疗开始或重新开始时，宫颈扩张超过3cm或消退超过50%的母亲所分娩的婴儿中，脐带异克舒令浓度超过2ng/ml的占77%，超过10ng/ml的占91%。如果仔细选择患者，大多数严重的新生儿问题是可以预防的。
