Kravchenko A T
Zh Mikrobiol Epidemiol Immunobiol. 1978 Nov(11):75-81.
In administration of bacterial exotoxins (diphtheria, botulinic) to guinea pigs in doses of 1/100 Dlm at an interval of one hour there developed a typical sickness with the lethal outcome in the course of 2-3 days from the beginning of the exotoxin administration. Low bacterial exotoxin doses induced allergic reaction of the organism before the cell producing specific antibodies began to act in defence. Lymphatic system cells responded rapidly to the low doses of bacterial exotoxins, but the process of formation of cells producing antibodies failed to reach mature plasmocytes, and no antibodies formed. With increase of the interval between the administration of low bacterial exotoxin doses to 24 hours specific antibodies did form, but these antibodies failed to protect the animals which were in the state of infectious allergy. The first stage of infectious allergy induced by low bacterial doses was nonspecific. Animals which were in the state of infectious allergy to diphtheria exotoxin perished of low botulinic (exotoxin) doses, and vice versa.
以1/100 Dlm的剂量、每隔一小时给豚鼠注射细菌外毒素（白喉毒素、肉毒毒素），从开始注射外毒素起2 - 3天内会出现典型病症并导致死亡。低剂量的细菌外毒素在产生特异性抗体的细胞开始发挥防御作用之前就引发了机体的过敏反应。淋巴系统细胞对低剂量细菌外毒素反应迅速，但产生抗体的细胞形成过程未能发育到成熟的浆细胞阶段，也未形成抗体。当低剂量细菌外毒素注射间隔延长至24小时时，确实形成了特异性抗体，但这些抗体未能保护处于感染性过敏状态的动物。低剂量细菌诱导的感染性过敏的第一阶段是非特异性的。对白喉外毒素处于感染性过敏状态的动物会死于低剂量肉毒（外毒素），反之亦然。
