Immunogenetic studies on low-density lipoprotein allotypes in chickens (Lcp1 and Lcp2).

Two blood plasma lipoprotein allotypes are described. Specific antiallotypic reagents were obtained from alloimmune precipitating sera produced against normal plasma and subsequently against lipoprotein fraction of d less than 1.072 g/ml. Identification studies by means of centrifugation and specific staining show that Lcp1 and Lcp2 are markers of the low-density lipoprotein class, 1.006 less than d less than 1.063 g/ml. Serological and genetic studies indicate that the two alloantigens behave as products of allelic genes, each occurring with varying frequencies in 20 lines studies. The Lcp1 antigen is always accompanied by Lcp2; however, the latter was also found to occur in plasma of birds lacking the Lcp1 marker.