Browning A K
Pharmatherapeutica. 1981;2(9):559-64.
A multi-centre study in general practice was carried out to compare the efficacy of two doses of cephalexin-500 mg or 1 g - given in a twice daily dosage regimen to 752 patients with respiratory or soft tissue infections. After 5-days' treatment, over 80% of the patients were cured or considerably improved, with no differences between the two treatment groups. Considering the lower respiratory and soft tissue infections together, 1 g cephalexin twice daily produced a better clinical response after 48-hours' treatment, suggesting a more rapid response with the higher dosage, but this trend did not reach statistical significance. Twice daily cephalexin therapy was also effective in patients with concurrent illness, and in those patients who had been treated unsuccessfully with other antibacterial therapy in the week prior to trial entry. No drug interactions were reported and the incidence of side-effects was low.
一项多中心全科医学研究对752例患有呼吸道或软组织感染的患者进行了比较，这752例患者被给予两种剂量（500毫克或1克）的头孢氨苄，采用每日两次的给药方案。经过5天的治疗，超过80%的患者被治愈或病情显著改善，两个治疗组之间没有差异。将下呼吸道感染和软组织感染合并考虑，每日两次服用1克头孢氨苄在治疗48小时后产生了更好的临床反应，表明较高剂量的反应更快，但这种趋势未达到统计学显著性。每日两次的头孢氨苄治疗对合并其他疾病的患者以及在试验入组前一周接受其他抗菌治疗未成功的患者也有效。未报告药物相互作用，且副作用发生率较低。
