Embryopathic effects of thromboxane B2 in the chick.

Several prostaglandins of the E and F series are now known to be involved in reproduction and developmental events. However, there is as yet no such evidence for any of the other arachidonate metabolites. Thromboxane B2 is the stable metabolic end product of the biologically active but unstable intermediate thromboxane A. Administered to developing chick embryos at 48 and 72 hours incubation, thromboxane B2 caused growth retardation and induced a high incidence of anomalies, in particular, everted viscera.