血栓素B2对鸡胚的胚胎病影响。
Embryopathic effects of thromboxane B2 in the chick.
作者信息
Gilani S H, Persaud T V
出版信息
Prostaglandins Med. 1981 Jun;6(6):627-31. doi: 10.1016/0161-4630(81)90124-5.
Several prostaglandins of the E and F series are now known to be involved in reproduction and developmental events. However, there is as yet no such evidence for any of the other arachidonate metabolites. Thromboxane B2 is the stable metabolic end product of the biologically active but unstable intermediate thromboxane A. Administered to developing chick embryos at 48 and 72 hours incubation, thromboxane B2 caused growth retardation and induced a high incidence of anomalies, in particular, everted viscera.
现已知道，E 系列和 F 系列的几种前列腺素参与生殖和发育过程。然而，对于其他任何花生四烯酸代谢产物，目前尚无此类证据。血栓素 B2 是生物活性但不稳定的中间体血栓素 A 的稳定代谢终产物。在孵化 48 小时和 72 小时时给予发育中的鸡胚，血栓素 B2 会导致生长迟缓并诱发高发生率的畸形，尤其是内脏外翻。
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