Murota S I, Morita I, Abe M
Biochim Biophys Acta. 1977 Nov 2;479(1):122-5. doi: 10.1016/0005-2787(77)90132-0.
The effects of thromboxane B2 and 6-ketoprostaglandin F1alpha on the synthesis of DNA, RNA and hexosamine-containing substances were studied. Thromboxane B2 (1 microgram/ml) added to cultures in the stationary phase caused the initiation of DNA synthesis and cell proliferation in a small proportion of cells. The same amount of thromboxane B2 also increased [3H]uridine incorporation into acid-insoluble fraction by 50% in 24 h, and stimulated the production of hexosamine-containing substances 2.5 fold over the control during the first 6 h. On the other hand, 6-ketoprostaglandin F1alpha was essentially inactive on these indexes except slight stimulation of DNA synthesis.
研究了血栓素B2和6-酮前列环素F1α对DNA、RNA和含己糖胺物质合成的影响。将血栓素B2（1微克/毫升）添加到稳定期培养物中，可使一小部分细胞开始DNA合成并发生细胞增殖。相同剂量的血栓素B2在24小时内还使[3H]尿苷掺入酸不溶性部分的量增加了50%，并在最初6小时内使含己糖胺物质的产生比对照增加了2.5倍。另一方面，6-酮前列环素F1α除了对DNA合成有轻微刺激外，对这些指标基本无活性。
