Anand B S, Piris J, Jerrome D W, Offord R E, Truelove S C
Q J Med. 1981;50(197):83-94.
Two treated subjects and one healthy volunteer have been challenged with a single dose of fraction B of gluten administered intraduodenally. Serial biopsy specimens were obtained by means of a Quinton hydraulically operated biopsy instrument immediately before challenge and repeatedly thereafter. The biopsy specimens were studied by light microscopy, electron microscopy, immunofluorescence, immunoperoxidase staining and disaccharidase assay. The two coeliac subjects showed pronounced mucosal changes which developed a few hours after challenge and which showed the features of an Arthus-type reaction. The healthy volunteer was unaffected. It is concluded that the lesion of coeliac disease is the result of an Arthus-type reaction induced by ingested gluten in susceptible subjects.
两名接受治疗的受试者和一名健康志愿者经十二指肠内给予单剂量麸质B组分进行激发试验。在激发试验前立即用昆顿液压活检器械获取系列活检标本，之后反复取材。活检标本通过光学显微镜、电子显微镜、免疫荧光、免疫过氧化物酶染色和双糖酶测定进行研究。两名乳糜泻受试者出现明显的黏膜变化，在激发试验后数小时出现，表现为阿图斯型反应的特征。健康志愿者未受影响。得出的结论是，乳糜泻的病变是易感受试者摄入麸质诱发的阿图斯型反应的结果。
