Bloom S R, Mitchell S J, Greenberg G R, Christofides N, Domschke W, Domschke S, Mitznegg P, Demling L
Acta Hepatogastroenterol (Stuttg). 1978 Oct;25(5):365-8.
Plasma VIP, secretin and motilin were measured in 9 volunteers following intraduodenal instillation of 50 ml of 0.1 mol/1 HCl over 3 minutes. VIP rose from 1.7 +/- 0.7 pmol/1 to a peak at 6 minutes of 6.6 +/- 0.9 pmol/1 and was still significantly elevated at 30 minutes. By comparison the elevation of secretin was more transitory rising from a basal value of 2.5 +/- 0.4 pmol/1 to a peak of 10 +/- 1.5 pmol/1 at 3 minutes and returning to baseline by 10 minutes. The rise of motilin, from a higher baseline, was intermediate in pattern, from 23 +/- 7 pmol/1 basally to a 4 minute peak of 40 +/- 10 pmol/1. Thus the elevation of VIP was the most longlasting, and while probably not of sufficient magnitude to stimulate pancreatic bicarbonate secretion via the circulation, could reflect a significant local role in regulating the response of the intestinal mucosa to acid.
在9名志愿者十二指肠内3分钟内滴注50毫升0.1摩尔/升盐酸后，检测了血浆中的血管活性肠肽（VIP）、促胰液素和胃动素。VIP从1.7±0.7皮摩尔/升升至6分钟时的峰值6.6±0.9皮摩尔/升，在30分钟时仍显著升高。相比之下，促胰液素的升高更短暂，从基础值2.5±0.4皮摩尔/升升至3分钟时的峰值10±1.5皮摩尔/升，并在10分钟时恢复到基线。胃动素从较高的基线上升，其模式处于中间状态，从基础值23±7皮摩尔/升升至4分钟时的峰值40±10皮摩尔/升。因此，VIP的升高持续时间最长，虽然其幅度可能不足以通过循环刺激胰腺分泌碳酸氢盐，但可能反映了其在调节肠黏膜对酸的反应中具有重要的局部作用。
