血管紧张素在家禽（原鸡）中的心血管作用。I. 分析。

Cardiovascular actions of angiotensin in the fowl (Gallus domesticus). I. Analysis.

作者信息

Moore A F, Strong J H, Buckley J P

出版信息

Res Commun Chem Pathol Pharmacol. 1981 Jun;32(3):423-45.

Abstract

Chicken aorta, unlike the aortae of any other species tested, did not respond to angiotensin II (AII) at concentrations up to 10(-4) M. The anesthetized chicken did, however, show a blood pressure increase in response to AII, but this was apparently dependent on the sympathetic nervous system. In the conscious chicken a biphasic response to AII was seen--an initial depressor response followed by a pressor response. The depressor response was not inhibited by standard blocking agents, but was blocked by prior induction of tachyphylaxis to vasopressin. It is concluded that the depressor response to AII in the conscious chicken is due to release of vasotocin, the avian equivalent to vasopressin, and the subsequent pressor response to AII is due to activation of the sympathetic nervous system.

摘要

与所测试的任何其他物种的主动脉不同，鸡的主动脉对浓度高达10⁻⁴ M的血管紧张素II（AII）无反应。然而，麻醉的鸡对AII有血压升高反应，但这显然依赖于交感神经系统。在清醒的鸡中，观察到对AII的双相反应——最初的降压反应随后是升压反应。降压反应不受标准阻断剂的抑制，但可被预先诱导对血管加压素产生快速耐受性所阻断。得出的结论是，清醒鸡对AII的降压反应是由于血管紧张素释放，它相当于鸟类的血管加压素，随后对AII的升压反应是由于交感神经系统的激活。