Concomitant analysis of normetanephrine and 3-methoxytyramine in brain: a new gas-liquid chromatography procedure.

A novel gas chromatographic procedure utilizing a glass capillary column and electron-capture detection is described for the simultaneous assay in brain of normetanephrine and 3-methoxytyramine, the 3-0-methylated metabolites or noradrenaline and dopamine respectively. The procedure has been used to quantitate these amines in whole rat brain and to demonstrate their post-mortem accumulation.