Satake K, Uchima K, Umeyama K, Appert H E, Howard J M
Surg Gynecol Obstet. 1981 Sep;153(3):341-5.
The coagulation changes observed in acute experimental pancreatitis were compared with those after the intravenous infusion of pancreatic juice and ascitic fluid exudate obtained from bile-induced pancreatitis in dogs. The coagulation changes after acute pancreatitis was induced by the intraductal injection of autologous bile, trypsin or elastase showed decreased platelet counts, decreased plasma fibrinogen levels, prolonged partial thromboplastin and prothrombin times, shortened euglobulin clot lysis time and increased fibrin degradation products. Multiple microemboli were observed in the lung and, occasionally, in the kidney, an indication of consumption coagulopathy. The effects upon blood coagulation after the intravenous injection of pancreatic juice included decreased platelet counts, decreased plasma fibrinogen levels and prolonged partial thromboplastin and prothrombin times. The intravenous injection of pancreatic exudate produced greater changes than did those of an equal amount of pancreatic juice. There was a shortening of euglobulin clot lysis time and a marked increase in fibrin degradation products. Pancreatic exudate which accumulates during acute pancreatitis may contain a toxic substance or substances which contribute to the consumption of coagulation factors during acute pancreatitis.
将急性实验性胰腺炎中观察到的凝血变化与静脉输注从犬胆汁性胰腺炎获得的胰液和腹水渗出液后的凝血变化进行比较。通过导管内注射自体胆汁、胰蛋白酶或弹性蛋白酶诱导急性胰腺炎后的凝血变化表现为血小板计数减少、血浆纤维蛋白原水平降低、部分凝血活酶时间和凝血酶原时间延长、优球蛋白凝块溶解时间缩短以及纤维蛋白降解产物增加。在肺中观察到多个微栓子，偶尔在肾脏中也有，这表明存在消耗性凝血病。静脉注射胰液后对血液凝固的影响包括血小板计数减少、血浆纤维蛋白原水平降低以及部分凝血活酶时间和凝血酶原时间延长。静脉注射胰腺渗出液比注射等量胰液产生的变化更大。优球蛋白凝块溶解时间缩短，纤维蛋白降解产物显著增加。急性胰腺炎期间积聚的胰腺渗出液可能含有一种或多种有毒物质，这些物质在急性胰腺炎期间会导致凝血因子的消耗。
