Sørennsen B, Rasmussen J P, Dauchot P J, Regula G
Acta Anaesthesiol Scand. 1978;22(6):615-21. doi: 10.1111/j.1399-6576.1978.tb01345.x.
In addition to the standard monitoring of heart rate and blood pressure, the Systolic Time Intervals were used to evaluate cardiac performance, and the Pressure Time Indices (tension time index = TTI; diastolic pressure time index = DPTI) were used to estimate myocardial oxygen balance. Twelve patients with known heart disease were studied during induction with thiopental, intubation, and early anesthesia with methoxyflurane. Cardiac performance diminished after thiopental; and during methoxyflurane it was reflected in increases in pre-ejection period (PEP) and the ratio PEP/LVET. Intubation resulted in a hyperactive state of the heart, as shown by maximal decreases in PEP and PEP/LVET. Myocardial oxygen balance--estimated from the supply/demand ratio (DPTI/TTI)--was impaired after thiopental. After intubation, DPTI/TTI decreased to its lowest value due to an excess of myocardial oxygen demand (TTI) over myocardial oxygen supply (DPTI), signifying a transitory underperfusion of the subendocardium. During methoxyflurane the oxygen balance was gradually restored towards control value. The Systolic Time Intervals and the Pressure Time Indices provided valuable information on cardiac function not available from standard monitoring alone.
除了对心率和血压进行标准监测外，还使用收缩期时间间期来评估心脏功能，并使用压力时间指数（张力时间指数=TTI；舒张压时间指数=DPTI）来估计心肌氧平衡。对12例已知心脏病患者在硫喷妥钠诱导、插管及甲氧氟烷早期麻醉期间进行了研究。硫喷妥钠给药后心脏功能下降；在甲氧氟烷麻醉期间，心脏功能下降表现为射血前期（PEP）及PEP/LVET比值增加。插管导致心脏处于亢进状态，表现为PEP及PEP/LVET的最大幅度下降。硫喷妥钠给药后，根据供应/需求比值（DPTI/TTI）估计的心肌氧平衡受到损害。插管后，由于心肌氧需求（TTI）超过心肌氧供应（DPTI），DPTI/TTI降至最低值，表明心内膜下出现短暂灌注不足。在甲氧氟烷麻醉期间，氧平衡逐渐恢复至对照值。收缩期时间间期和压力时间指数提供了关于心脏功能的有价值信息，这些信息是仅通过标准监测无法获得的。
