Eriksen S, Johannsen G, Frost N
Acta Anaesthesiol Scand. 1980;24(1):74-8. doi: 10.1111/j.1399-6576.1980.tb01509.x.
The effects of inhalation of oxygen, nitrous oxide/oxygen and nitrous oxide/nitrogen/oxygen on systolic time intervals (PEP (pre-ejection period) and LVET (left ventricular ejection time) were investigated in eight healthy persons. Nitrous oxide 40%, administered with oxygen or oxygen/nitrogen, prolonged PEP significantly by 25% and 22%, respectively. Inhalation of oxygen also prolonged PEP but to a significantly minor degree. LVET, heart rate and MAP were unchanged during the experiments. Derivatives from the systolic time intervals, i.e. PEP/LVET, I/PEP2 and ejection fraction changed significantly in the nitrous oxide groups. It is concluded that nitrous oxide depresses cardiac performance, to some degree, even when administered at a rather low concentration.
在8名健康受试者中，研究了吸入氧气、氧化亚氮/氧气以及氧化亚氮/氮气/氧气对收缩期时间间期（射血前期（PEP）和左心室射血时间（LVET））的影响。40%的氧化亚氮与氧气或氧气/氮气一起给药时，分别使PEP显著延长25%和22%。吸入氧气也会延长PEP，但程度显著较小。实验过程中LVET、心率和平均动脉压（MAP）未发生变化。收缩期时间间期的衍生指标，即PEP/LVET、1/PEP2和射血分数在氧化亚氮组中发生了显著变化。得出的结论是，即使以相当低的浓度给药，氧化亚氮在一定程度上也会抑制心脏功能。
