Newland J R, Mackay B, Hill C S, Hickey R C
Ultrastruct Pathol. 1981 Apr-Jun;2(2):121-9. doi: 10.3109/01913128109064240.
Anaplastic carcinoma of the thyroid is an aggressive, rapidly fatal neoplasm that is generally believed to arise from the epithelium of the thyroid follicle. When differentiated carcinoma is not present, the diagnosis can be difficult and confusion with a sarcoma is frequently a problem. Ten anaplastic thyroid carcinomas have been examined by light and electron microscopy and compared with two biologically aggressive, solid follicular carcinomas. Ultrastructural study revealed evidence of epithelial differentiation in all the anaplastic carcinomas, confirming their origin from thyroid follicular cells. The study illustrates the value of electron microscopy in establishing the diagnosis of anaplastic carcinoma and in differentiating it from sarcoma.
甲状腺间变性癌是一种侵袭性强、迅速致死的肿瘤，一般认为它起源于甲状腺滤泡上皮。当不存在分化型癌时，诊断可能会很困难，且常出现与肉瘤混淆的问题。我们通过光镜和电镜检查了10例甲状腺间变性癌，并与2例生物学行为侵袭性强的实性滤泡癌进行了比较。超微结构研究显示，所有间变性癌均有上皮分化的证据，证实它们起源于甲状腺滤泡细胞。该研究说明了电镜在甲状腺间变性癌诊断及与肉瘤鉴别诊断中的价值。
