Hayashi Y, Tokuoka S
Acta Pathol Jpn. 1979 Jan;29(1):119-33. doi: 10.1111/j.1440-1827.1979.tb01297.x.
Four cases of anaplastic carcinoma of the thyroid, composed of one small cell carcinoma and three giant cell carcinomas, were studied with electron microscope. In the case of small cell carcinoma, fine cytoplasmic interdigitations and junctional complex between apposing cytoplasmic membranes of neighbouring tumor cells and a few microlumina within tumor cell clusters surrounded by well-defined basal lamina were seen. In the cases of giant cell carcinoma, occasional cytoplasmic interdigitations as well as desmosomal structures were detected even in tumor cells markedly pleomorphic and anaplastic. Abundant cytoplasmic organelles including profiles of Golgi apparatus, rough endoplasmic reticulum and a few mitochondria were seen in the cytoplasm of tumor cell of all four cases. Of interest to note was that all giant cell carcinomas demonstrated evidences of fairly well differentiated tumor within anaplastic carcinoma, indicating probable pre-existing either benign or malignant epithelial neoplasm more differentiated, with its subsequent anaplastic transformation. Findings in the present study support an assumption that these anaplastic tumors are derived from the follicular epithelium of the thyroid gland. In addition, it can be said that tumor cells of the small cell carcinoma provide evidences suggesting functional differentiation of carcinoma cells to a certain extent, yet unable to produce thyroglobulin.
对4例甲状腺间变性癌进行了电镜研究，其中包括1例小细胞癌和3例巨细胞癌。在小细胞癌病例中，可见到肿瘤细胞相邻细胞质膜之间的精细细胞质交错和连接复合体，以及由明确的基膜包围的肿瘤细胞簇内的一些微腔隙。在巨细胞癌病例中，即使在明显多形性和间变的肿瘤细胞中，也偶尔检测到细胞质交错以及桥粒结构。在所有4例病例的肿瘤细胞胞质中均可见到丰富的细胞质细胞器，包括高尔基体、粗面内质网和一些线粒体的形态。值得注意的是，所有巨细胞癌在间变性癌内均显示出分化较好的肿瘤证据，表明可能先前存在分化程度更高的良性或恶性上皮性肿瘤，随后发生了间变转化。本研究结果支持这些间变性肿瘤起源于甲状腺滤泡上皮的假设。此外，可以说小细胞癌的肿瘤细胞提供了证据，表明癌细胞在一定程度上具有功能分化，但不能产生甲状腺球蛋白。
