Fenger C, Knoth M
Ultrastruct Pathol. 1981 Apr-Jun;2(2):163-73. doi: 10.3109/01913128109064245.
The ultrastructure of the anal transitional zone (ATZ) is described by means of scanning and transmission electron microscopy. The technique used permits histologic reexamination of the scanning electron microscopic biopsies. The surface of the ATZ shows, in addition to areas of normal colorectal mucosa and squamous epithelium, a characteristic picture: there are cells of varying size, arranged in a cobblestone pattern, and a surface covered with short microvilli that tend to form rows, indicating beginning microridge formation. This corresponds histologically to the so-called ATZ epithelium, and it is suggested that this might be metaplastic squamous epithelium rather than urothelium. The deepest part of the epithelium contains endocrinelike cells with granules of at least two types.
通过扫描电子显微镜和透射电子显微镜描述了肛管移行区（ATZ）的超微结构。所使用的技术允许对扫描电子显微镜活检组织进行组织学复查。ATZ的表面除了有正常结直肠黏膜和鳞状上皮区域外，还有一幅特征性图像：有大小各异的细胞，呈鹅卵石样排列，表面覆盖着倾向于成行排列的短微绒毛，表明微嵴开始形成。这在组织学上与所谓的ATZ上皮相对应，有人认为这可能是化生的鳞状上皮而非尿路上皮。上皮的最深部分含有至少两种类型颗粒的内分泌样细胞。
