Labeeuw M, Gerbaulet C, Pozet N, Zech P, Traeger J
Urol Res. 1981;9(4):163-8. doi: 10.1007/BF00264821.
It has been suggested recently that the first step in the formation of calcium oxalate stones appears to be crystallisation. This step is said to depend on the state of saturation of the urine. This hypothesis was checked in cystine stone formers. Cystine crystalluria was found in 83% of 24 urine samples from cystine stone formers (CSF) but in one of the 400 control samples and appears to be a good guide in the diagnosis of cystine lithiasis. Urinary cystine saturation was constantly higher in CSF than in non-cystine stone formers (NCSF) who exhibited undersaturated urine with respect to cystine. There was almost no overlap between these 2 groups. Crystals were never found in undersaturated urine and were always present when the saturation was above 1. There appears to be a good correlation between the level of urinary saturation and the presence of crystalluria and there is no need for any additional factor such as a defective inhibitor. The study underlines the limits of a therapeutic regimen of a high fluid intake and alkalinisation of the urine.
最近有人提出，草酸钙结石形成的第一步似乎是结晶。据说这一步取决于尿液的饱和状态。在胱氨酸结石患者中对这一假设进行了验证。在24例胱氨酸结石患者（CSF）的尿液样本中，83%发现有胱氨酸结晶尿，但在400例对照样本中仅有1例出现，这似乎是诊断胱氨酸结石的一个很好的指标。CSF患者的尿胱氨酸饱和度始终高于非胱氨酸结石患者（NCSF），后者的尿液相对于胱氨酸呈不饱和状态。这两组之间几乎没有重叠。在不饱和尿液中从未发现晶体，而当饱和度高于1时晶体总是存在。尿饱和度水平与结晶尿的存在之间似乎有很好的相关性，并且不需要任何额外的因素，如缺陷抑制剂。该研究强调了高液体摄入量和尿液碱化治疗方案的局限性。
