Landon G V, Pryor J P
Virchows Arch A Pathol Anat Histol. 1981;392(3):355-64. doi: 10.1007/BF02155671.
The permeability of the blood-testis barrier was studied in 41 men of diverse fertility status by observing the distribution of lanthanum, and electron-opaque tracer administered during immersion fixation of testicular biopsies. Evidence for barrier mechanisms operating at the specialised tight junctions between Sertoli cells was seen in all specimens. In approximately one half of the seminiferous tubules examined this barrier appeared to be less effective as seen by the penetration of lanthanum past the Sertoli cell tight junctions. This phenomenon was found to be significantly related to both the tubular spermatogenetic activity as measured by a scoring method and the presence of subcellular changes in the Sertoli cells. A depression of spermatogenesis was associated with an increase in the incidence of tubules with apparently defective tight junctions. In men with obstructive azoospermia there was no increase in the incidence of this phenomenon.
通过观察镧（一种电子不透明示踪剂）在睾丸活检浸入固定过程中的分布情况，对41名生育状况各异的男性的血睾屏障通透性进行了研究。在所有标本中均可见到支持在支持细胞之间特化紧密连接处起作用的屏障机制的证据。在所检查的约一半生精小管中，镧穿过支持细胞紧密连接处，表明该屏障似乎效力较低。发现这种现象与通过评分法测量的生精小管生精活性以及支持细胞亚细胞变化的存在均显著相关。精子发生抑制与紧密连接处明显有缺陷的小管发生率增加有关。在梗阻性无精子症男性中，这种现象的发生率并未增加。
