Carlsson S, Kullander S
Acta Obstet Gynecol Scand. 1981;60(3):287-90. doi: 10.3109/00016348109158132.
Specific localization in vivo of marked, 131I-labelled human chorionic gonadotrophin (HCG) was shown by scintillation counting of different tissues to occur in rat ovarian tumor, but not in human Krukenberg tumor heterografts growing subcutaneously in female nude mice. The ovaries of the mice showed an increased uptake. This model system may be useful for studying gonadotrophin receptors and gonadotrophin dependency of human ovarian tumors. A similar study in menstruating women about to be operated upon because of myoma showed a remarkably high uptake in the corpus luteum, but binding also in ovarian follicles. The increased uptake of the radioactivity observed in the ovaries enabled preliminary scanning. This unique specificity of uptake may offer new possibilities in the diagnosis of ovarian tumors. The general turnover of the 131I-HCG in these women is described and applied to a mathematical model. High relative concentrations of 131I were also seen in urine and saliva.
通过对不同组织进行闪烁计数表明，标记的131I 人绒毛膜促性腺激素（HCG）在体内的特异性定位发生在大鼠卵巢肿瘤中，但在雌性裸鼠皮下生长的人克鲁肯伯格瘤异种移植物中未出现。小鼠的卵巢摄取增加。该模型系统可能有助于研究人卵巢肿瘤的促性腺激素受体和促性腺激素依赖性。一项针对因肌瘤即将接受手术的月经周期女性的类似研究显示，黄体摄取非常高，但卵巢卵泡中也有结合。在卵巢中观察到的放射性摄取增加使得能够进行初步扫描。这种独特的摄取特异性可能为卵巢肿瘤的诊断提供新的可能性。描述了这些女性体内131I-HCG的一般周转率并将其应用于数学模型。尿液和唾液中也观察到相对较高浓度的131I。
