Marciniak M
Acta Physiol Pol. 1981 Mar-Apr;32(2):193-204.
With progressing advances in radioisotope diagnostic methods in nuclear medicine new radiopharmaceutic agents have been introduced containing inorganic soluble compounds of bivalent tin (Sn+2). An important problem is to study the metabolism and toxicological effects of Sn+2. In the presently reported work the distribution of Sn+2 was determined in the organism of rats at different time intervals after intravenous administration of 113SnCl2 (from 10 minutes to 4 months) and the rate of its elimination from the whole body was studied. Sn+2 toxicity was determined calculating the LD50/30 dose of Sn+2 and by means of the OCT test (ornithine-carbamyltransferase level in the serum). The investigation demonstrated selective accumulation of Sn+2 in the liver and spleen where it remained for a long time, phasic elimination of tin from the whole body, and its moderate toxicity after intravenous administration.
随着核医学放射性同位素诊断方法的不断进步，已引入了含有二价锡（Sn+2）无机可溶性化合物的新型放射性药物制剂。一个重要的问题是研究Sn+2的代谢和毒理学效应。在目前报道的工作中，在静脉注射113SnCl2后不同时间间隔（从10分钟到4个月）测定了大鼠体内Sn+2的分布，并研究了其从全身消除的速率。通过计算Sn+2的LD50/30剂量并借助OCT试验（血清中鸟氨酸-氨甲酰基转移酶水平）来确定Sn+2的毒性。研究表明，Sn+2在肝脏和脾脏中选择性蓄积并长时间留存，锡从全身呈阶段性消除，静脉注射后其毒性中等。
