Pfaff K, Kujawa M, Macholz R M, Woggon H
Arch Exp Veterinarmed. 1980;34(3):353-6.
Tin incorporated in baker's yeast was applied to male Wistar rats over 21 days. The doses corresponded to 1/500 or 1/50 of LD50 of SnCl2 x 2H2O and 1/50 of LD50 of SnCl2 x 2H2O. The effects on activities of certain selected enzymes as well as on tin levels in liver and kidneys were tested. Some of the enzymes tested were found to reflect even exposures much below the point recordable from accumulation of the metal. Serum lactate-dehydrogenase is recommended as a sensitive indicator enzyme in the context of tin exposure.
将添加到面包酵母中的锡应用于雄性Wistar大鼠21天以上。剂量相当于SnCl₂·2H₂O的LD₅₀的1/500或1/50以及SnCl₂的LD₅₀的1/50。测试了对某些选定酶活性以及肝脏和肾脏中锡水平的影响。发现一些被测酶甚至能反映远低于金属积累可记录点的暴露情况。在锡暴露的情况下，推荐血清乳酸脱氢酶作为一种敏感的指示酶。
