Rao P S, Cavanagh D, Gaston L W
Am J Obstet Gynecol. 1981 Aug 15;140(8):914-22. doi: 10.1016/0002-9378(81)90085-5.
A primate model was utilized to study the cardiovascular and coagulation effects of endotoxic shock. The therapeutic effectiveness of drugs such as aspirin and dipyridamole, which diminish platelet aggregation and adherence, were evaluated. From the data, it appears that the kidney is a target organ in endotoxic shock, at least when a bolus injection of endotoxin is administered. The precipitate falls in the renal artery flow (p less than 0.01) and platelet count (p less than 0.01), which occur 3 minutes after the intravenous injection of endotoxin, can be prevented in part by pretreatment with aspirin (40 mg/kg of body weight). The changes in the coagulation profile were of less magnitude, and the fibrin degradation products appeared late in the group pretreated with aspirin as compared to the other groups. The combination of dipyridamole and aspirin was not as effective as aspirin alone in achieving the apparently protective effect. The study suggests that the administration of aspirin to patients with gram-negative infections may be beneficial.
利用灵长类动物模型研究内毒素休克对心血管和凝血的影响。评估了阿司匹林和双嘧达莫等可减少血小板聚集和黏附的药物的治疗效果。从数据来看，至少在大剂量注射内毒素时，肾脏是内毒素休克的靶器官。静脉注射内毒素3分钟后出现的肾动脉血流量下降（p<0.01）和血小板计数下降（p<0.01），可通过预先给予阿司匹林（40mg/kg体重）得到部分预防。与其他组相比，阿司匹林预处理组的凝血指标变化幅度较小，纤维蛋白降解产物出现较晚。双嘧达莫和阿司匹林联合使用在实现明显的保护作用方面不如单独使用阿司匹林有效。该研究表明，对革兰氏阴性感染患者使用阿司匹林可能有益。
